David K Meyerholz Selected Research

Neoplasms (Cancer)

1/2023	CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.
1/2022	Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo.
1/2020	Validating indicators of CNS disorders in a swine model of neurological disease.
1/2020	RABL6A Is an Essential Driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tumor Cells to CDK4/6 Inhibitors.
1/2018	5'-methylschweinfurthin G reduces chondrosarcoma tumor growth .
1/2018	Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.
11/2014	Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen.
9/2014	Development and translational imaging of a TP53 porcine tumorigenesis model.
1/2014	NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.
7/2013	Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.

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David K Meyerholz Research Topics

Disease

49	Infections 01/2024 - 07/2004
27	Inflammation (Inflammations) 12/2022 - 10/2004
21	Cystic Fibrosis (Mucoviscidosis) 05/2024 - 10/2004
17	COVID-19 02/2024 - 01/2020
16	Neoplasms (Cancer) 01/2023 - 07/2007
10	Lung Diseases (Lung Disease) 04/2024 - 06/2009
10	Pneumonia (Pneumonitis) 01/2023 - 05/2004
9	Virus Diseases (Viral Diseases) 07/2021 - 05/2004
9	Respiratory Syncytial Virus Infections 01/2020 - 01/2006
6	Asthma (Bronchial Asthma) 01/2023 - 07/2013
5	Hypertension (High Blood Pressure) 01/2019 - 09/2015
5	Pancreatitis 01/2013 - 11/2007
4	Meconium Ileus 04/2024 - 09/2008
4	Coronavirus Infections 12/2023 - 12/2015
4	Paramyxoviridae Infections (Parainfluenza) 07/2021 - 05/2004
4	Weight Loss (Weight Reduction) 01/2021 - 02/2015
3	Hemorrhage 01/2022 - 01/2005
3	Body Weight (Weight, Body) 01/2022 - 08/2007
3	Human Influenza (Influenza) 12/2021 - 07/2008
3	Severe Acute Respiratory Syndrome 02/2016 - 11/2009
3	Respiratory Tract Infections (Respiratory Tract Infection) 10/2015 - 11/2011
3	Necrosis 10/2011 - 05/2005
3	Burns 08/2010 - 02/2009
2	Sepsis (Septicemia) 12/2023 - 08/2010
2	Hyperalgesia 07/2023 - 11/2019
2	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 01/2020
2	Retinoblastoma (Glioblastoma, Retinal) 01/2023 - 01/2020
2	Neurofibrosarcoma (MPNST) 01/2023 - 01/2020
2	Fibrosis (Cirrhosis) 10/2022 - 11/2009
2	B-Cell Lymphoma (Lymphoma, B Cell) 10/2022 - 04/2016
2	Obesity 01/2022 - 01/2020
2	Insulin Resistance 01/2022 - 01/2020
2	Edema (Dropsy) 01/2022 - 01/2013
2	Primitive Neuroectodermal Tumors (PNET) 06/2021 - 01/2019
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2020 - 11/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 11/2019 - 10/2018
2	Pain (Aches) 11/2019 - 01/2018
2	Cardiomegaly (Heart Hypertrophy) 01/2019 - 09/2015
2	Persistent Infection 01/2018 - 09/2012

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 10/2023 - 05/2004
17	CytokinesIBA 12/2022 - 10/2005
13	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 05/2024 - 08/2008
9	VaccinesIBA 02/2024 - 03/2015
8	Antiviral Agents (Antivirals)IBA 12/2023 - 01/2007
7	AntigensIBA 01/2018 - 11/2004
6	Surface-Active Agents (Surfactants)IBA 03/2016 - 05/2004
5	Angiotensin-Converting Enzyme 2IBA 01/2024 - 01/2007
5	Messenger RNA (mRNA)IBA 01/2022 - 05/2004
5	MucinsIBA 01/2022 - 05/2011
5	RNA (Ribonucleic Acid)IBA 10/2020 - 07/2007
5	AnionsIBA 09/2017 - 03/2011
5	Ethanol (Ethyl Alcohol)IBA 11/2011 - 08/2007
5	beta-DefensinsIBA 01/2006 - 05/2004
4	Glycoproteins (Glycoprotein)IBA 01/2022 - 05/2011
4	InterferonsIBA 01/2021 - 02/2015
3	OxidesIBA 01/2023 - 04/2020
3	IronIBA 01/2022 - 11/2009
3	Prostaglandin D2IBA 01/2022 - 01/2017
3	Phospholipases (Phospholipase)IBA 01/2022 - 10/2015
3	Biomarkers (Surrogate Marker)IBA 06/2021 - 04/2020
3	AntibodiesIBA 01/2020 - 05/2011
3	Phosphotransferases (Kinase)IBA 01/2020 - 11/2008
3	ErbB Receptors (EGF Receptor)IBA 01/2020 - 06/2013
3	Angiotensin IIIBA 01/2019 - 09/2015
3	Interleukin-10 (Interleukin 10)IBA 01/2019 - 01/2007
3	Respiratory Syncytial Virus VaccinesIBA 03/2015 - 02/2008
3	ChemokinesIBA 02/2015 - 01/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2011 - 01/2007
3	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 01/2008 - 05/2004
2	EnzymesIBA 01/2024 - 01/2022
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2023 - 01/2020
2	CopperIBA 01/2023 - 01/2022
2	prostaglandin D2 receptorIBA 01/2022 - 04/2021
2	Insulin (Novolin)FDA Link 01/2022 - 08/2010
2	EicosanoidsIBA 01/2022 - 04/2021
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2015
2	Amyloid (Amyloid Fibrils)IBA 01/2022 - 05/2005
2	asapiprantIBA 01/2022 - 04/2021
2	COVID-19 VaccinesIBA 07/2021 - 04/2021
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2021 - 01/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 03/2014
2	InterleukinsIBA 01/2021 - 01/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 02/2015
2	Phenobarbital (Luminal)FDA Link 11/2020 - 12/2013
2	Neutralizing AntibodiesIBA 01/2020 - 10/2014
2	Neurofibromin 1 (Neurofibromin)IBA 01/2020 - 11/2019
2	LigandsIBA 01/2020 - 01/2019
2	Nicotine FDA Link 01/2019 - 10/2016
2	Cholinergic Agents (Cholinergics)IBA 01/2019 - 10/2016
2	Interleukin-8 (Interleukin 8)IBA 01/2018 - 07/2004
2	CollagenIBA 01/2018 - 02/2009
2	CalciumIBA 01/2018 - 04/2016
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 10/2017 - 07/2013
2	ProstaglandinsIBA 01/2017 - 02/2010
2	Interferon Type IIBA 02/2016 - 09/2009

Therapy/Procedure

20	Therapeutics 01/2024 - 10/2004
6	Ligation 12/2023 - 11/2007
3	Injections 07/2023 - 07/2011
3	Lasers (Laser) 11/2019 - 01/2006
2	Lung Transplantation 10/2022 - 01/2018